- The Peter Doherty Institute for Infection and Immunity
|Associate Professor Siddhartha Mahantyfirstname.lastname@example.org||Personal web page|
- Characterisation of antibodies against Plasmodium falciparum gametocytes to elucidate mechanisms of transmission blocking immunity
Immunity against sexual stage, that underpin transmission-blocking immunity (TBI), directed at parasite molecules expressed in the gametocyte through to ookinete stages are not well-understood. Antibodies (Ab) specific to these molecules are likely be crucial for TBI. We propose to characterise the sexual stage Ab targets in Plasmodium falciparum (Pf), the cause of the most severe form of malaria, and to better understand the properties of Abs that confer TBI. The goals of this project are to functionally characterise anti-gametocyte antibodies in sera from malaria-infected individuals that mediate TBI using biochemical and immunological techniques.
- Micro-RNA and severity of clinical malaria
Infection with Plasmodium falciparum (Pf) ranges in severity from asymptomatic parasitaemia to severe or fatal disease. Host- and parasite-derived factors are involved in determining severity of illness. Pf-infected red blood cells (iRBC) release small membrane particles, called extracellular vesicles (EV), into the circulation that directly interact with and influence host cells through the proteins and nucleic acids (RNA/DNA). EV are capable of transporting functional micro-RNA (miRNA). The goal of this project is to determine if extracellular vesicles in circulation and/or extracellular miRNA associated with vesicles contribute to the regulation of the clinical severity of falciparum malaria.
- Siddhartha Mahanty (Group leader)
- Prof. Stephen Rogerson, Theme leader
- David Grimson (MBioMedSci student)
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