Gene-environment interactions in depression

Project Details

In collaboration with Professor Jane Gunn (Department of General Practice) we examine the interplay between genetic variation and environments in the largest and longest running prospective study of primary care attendees with depressive symptoms in Australia (diamond). We are particularly interested in the interaction between genes and adverse events such as childhood abuse but are also examining interactions with positive environments (e.g. social support).

Funding

  • L.E.W. Carty Charitable Fund
  • NHMRC
  • Beyond Blue

Research Publications

Nguyen T, Gunn JM, Potiriadis M, Everall IP, Bousman CA. Serotonin transporter polymorphism (5HTTLPR), severe childhood abuse, and depressive symptom trajectories in adulthood. British Journal of Psychiatry Open 2015, 1(1): 104-109

Bousman, C.A., Potiriadis, M., Everall, I.P., Gunn, J.M.. G-protein B3 subunit genetic variation moderates five-year depressive symptom trajectories of primary care attendees. Journal of Affective Disorders 2014, 165: 64-68.

Bousman, C.A., Potiriadis, M., Everall, I.P., Gunn, J.M. Effect of neuregulin-1 (NRG1) genetic variation and depression symptom severity on longitudinal patterns of psychotic symptoms in primary care attendees. American Journal Medical Genetics Part B: Neuropsychiatric Genetics 2014, 165 (1): 62-67.

Bousman, C.A., Potiriadis, M., Everall, I.P., Gunn, J.M. Methylentetrahydrofolate reductase (MTHFR) genetic variation and major depressive disorder prognosis: A five-year prospective cohort study of primary care attendees. American Journal Medical Genetics Part B: Neuropsychiatric Genetics 2014, 165 (1): 68-76.

Research Group

Melbourne Neuropsychiatry Centre Research



Faculty Research Themes

Neuroscience

School Research Themes

Neuroscience and Psychiatry



Key Contact

For further information about this research, please contact the research group leader.

Department / Centre

Psychiatry