Understanding the role of CXCR7 in lymphodema following radiation injury

Research Opportunity
PhD, Masters by Research, Honours, Master of Biomedical Science
Project Status
Future
Department
Surgery
Location
St Vincent's Hospital
Supervisor Email Number Webpage
Dr Tara Karnezis Personal web page
Dr Ramin Shayan Personal web page

Project Details

The range of cancers for which radiotherapy is being used is ever expanding with unavoidable dose exposure that occurs in surrounding normal cells.  This radiation exposure does not have the effect of simply killing normal cells; but elicits a permanent damage or injury profile that not only persists, but continues to evolve throughout the life of the patient. These changes result in ongoing tissue contracture, pain, lymphodema, and tissue breakdown; in turn leading to significant disability, impairment of quality of life, infection, and potentially life-threatening exposure of vital structures. We have performed a raft of functional bioassays to specifically interrogate the key functions of lymphatic endothelial cells during the course of radiation induced lymphodema and have developed genomic, proteomic and metabolic platforms to understand the key signalling and communication pathways between lymphatic endothelial cells and their microenvironment critical for disease evolution. CXCR7, a chemokine receptor was one such gene shown to be differentially expressed during radiation injury. We would like to understand the role of this orphan receptor in radiation injury in animal models of radiation-induced lymphodema. The project will develop skills in cell biology, cell purification, FACs, bioinformatics and genetic mouse models.

This project is conducted in St Vincent’s Institute of Medical Research, Lympathic and Regenerative Surgery Group, (O’Brien Institute Department of SVI).



Faculty Research Themes

Cancer

School Research Themes

Cancer in Medicine



Research Opportunities

PhD, Masters by Research, Honours, Master of Biomedical Science Graduate Research Students who are interested in joining this project will need to consider their elegibility as well as other Graduate Research requirements before contacting the supervisor of this research

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Key Contact

For further information about this research, please contact a supervisor.

Department

Surgery

Research Node

St Vincent's Hospital