Ubiquitination and Fanconi Anemia

Research Opportunity
PhD, Masters by Research, Honours, Master of Biomedical Science
Project Status
Future
Department
Medicine and Radiology
Location
St Vincent's Hospital
Supervisor Email Number Webpage
Dr Andrew Deans Personal web page

Project Details

Ubiquitin is a small protein that is covalently attached to proteins to alter their function. In the cancer predisposition disorder Fanconi anemia, defective FANCA some how causes the attachment of ubiquitin to FANCD2 to fail. This apparently simple defect results in phenotypes of bone marrow failure, developmental problems and increased rates of leukaemia and solid tumours.

We have developed a biochemical system to study this important ubiquitination reaction.  This project aims to test the biochemical mechanism by which this ubiquitination occurs, and how FANCA protein works in the reaction. A combination of approaches using the latest technologies will also test how patient associated mutations in FANCA cause Fanconi Anaemia.  This will be combined with cell-based assays investigating the mechanism by which defects in ubiquitination lead to leukaemia predisposition.

This project is conducted in St Vincent’s Institute of Medical Research, Genome Stability Unit.



Faculty Research Themes

Cancer

School Research Themes

Cancer in Medicine



Research Opportunities

PhD, Masters by Research, Honours, Master of Biomedical Science Graduate Research Students who are interested in joining this project will need to consider their elegibility as well as other Graduate Research requirements before contacting the supervisor of this research

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Key Contact

For further information about this research, please contact a supervisor.

Department

Medicine and Radiology

Research Group / Unit / Centre

Research Node

St Vincent's Hospital