Structural biology of proteins involved in mental illnesses

Research Opportunity
PhD, Masters by Research, Honours, Master of Biomedical Science
Project Status
Future
Department
Medicine and Radiology
Location
St Vincent's Hospital
Supervisor Email Number Webpage
Prof Michael Parker Personal web page

Project Details

Alzheimer’s disease (AD) is the fourth biggest killer in developed countries. Amyloid precursor protein (APP) plays a central role in the development of AD, through generation of the toxic Abeta peptide by proteolytic breakdown of APP. Here we will use X-ray crystallography at the Australian Synchrotron to determine the 3D atomic structures of Abeta bound to therapeutic antibodies currently in clinical trials in order to understand how these molecules recognise Abeta. We use this information to engineer more potent antibodies as treatments for AD. We also have structure-based drug discovery projects on APP itself and other proteins involved in the production and clearance of the Abeta peptide from the brain.

This project is conducted in St Vincent’s Institute of Medical Research, Structural Biology Unit.



Faculty Research Themes

Neuroscience

School Research Themes

Neuroscience & Psychiatry



Research Opportunities

PhD, Masters by Research, Honours, Master of Biomedical Science Graduate Research Students who are interested in joining this project will need to consider their elegibility as well as other Graduate Research requirements before contacting the supervisor of this research

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Key Contact

For further information about this research, please contact a supervisor.

Department

Medicine and Radiology

Research Group / Unit / Centre

Research Node

St Vincent's Hospital