Development of scaffolds for restoration of myotendous junctions

Research Opportunity
PhD, Masters by Research, Honours, Master of Biomedical Science
Project Status
Future
Department
Medicine and Radiology
Location
St Vincent's Hospital
Supervisor Email Number Webpage
A/Prof Robert Kapsa r.kapsa@unimelb.edu.au 03 9288 3340 Personal web page

Project Details

Damage to muscle tissue resulting from trauma poses significant problems for orthopaedic surgeons attempting to save limbs and recover joint function. Likewise, it is currently beyond the scope of regenerative therapies to restore lost muscle function arising from disease-related loss of muscle tissue. World-wide, musculoskeletal conditions affect more than 1 in every 100 people and the prognosis for regeneration and long-term success for good functional outcomes is poor.

This project focuses on two aspects central to the restoration of compromised muscle; (i) re-establishing the myotendonous junction to restore articulation of limb joints.

Therefore, the key aims of this project are:

  • To develop bioactive polymeric scaffolds that support implanted cultured myocytes and neurons to build 3D tissue suitable for restorative and regenerative surgery;
  • To devise a biomimetic approach by using biologically active factors incorporated into the material structure of the scaffolds to promote the growth and differentiation of tissue to stimulate neuromuscular junction formation.

This project will utilize cultured adult stem cells that will be differentiated into required cell types on supporting 3D polymer scaffolds developed as part of a collaborative link with the Intelligent Polymer Research Institute at the University of Wollongong.



Faculty Research Themes

Neuroscience

School Research Themes

Neuroscience & Psychiatry, Musculoskeletal



Research Opportunities

PhD, Masters by Research, Honours, Master of Biomedical Science
Graduate Research Students who are interested in joining this project will need to consider their elegibility as well as other Graduate Research requirements before contacting the supervisor of this research

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Key Contact

For further information about this research, please contact a supervisor.

Department

Medicine and Radiology

Research Group / Unit / Centre

Clinical Neurosciences

Research Node

St Vincent's Hospital