Non-alcoholic fatty liver disease – characterising disease features in order to develop new therapies

Research Opportunity
PhD, Masters by Research, Honours, Master of Biomedical Science
Project Status
Future
Department
Medicine and Radiology
Location
St Vincent's Hospital
Supervisor Email Number Webpage
Dr Amanda Edgley aedgley@unimelb.edu.au Personal web page
Dr Fay Khong Personal web page

Project Details

Non-alcoholic Fatty Liver Disease is the most common chronic liver disorder in developed countries, affecting up to 30% of the population. 10-20% of NAFLD patients will progress to non-alcoholic steatohepatitis, in which inflammatory processes are activated in the liver. NASH can then progress to more advanced liver diseases, including cirrhosis and even hepatocellular carcinoma. Previous studies have demonstrated that individuals with obesity, diabetes and insulin resistance have an increased risk of NAFLD and disease progression. Currently, no effective treatments have been shown to alter the natural history of NAFLD progression. Research efforts to understand the pathogenesis of NAFLD progression are hampered by the lack of a robust animal model. This project involves characterisation of the histological and molecular features of a high fat, high cholesterol fed animal model of NAFLD/NASH and investigation of new molecular targets that could be involved in the disease pathogenesis.


School Research Themes

Cardiometabolic



Research Opportunities

PhD, Masters by Research, Honours, Master of Biomedical Science Graduate Research Students who are interested in joining this project will need to consider their elegibility as well as other Graduate Research requirements before contacting the supervisor of this research

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Key Contact

For further information about this research, please contact a supervisor.

Department

Medicine and Radiology

Research Node

St Vincent's Hospital