NMDA receptor antagonists and cognitive dysfunction

Research Opportunity
PhD, Masters by Research, Honours, Master of Biomedical Science
Project Status
Future
Department
Medicine and Radiology
Location
Royal Melbourne Hospital
Supervisor Email Number Webpage
Nigel Jones Personal web page

Project Details

NMDA receptors are ion channels involved in many aspects of neural communication and neural plasticity. Deficits in the signalling through NMDA receptors is associated with learning and memory impairments, although the specific mechanisms underlying this consequence is not clear. Here, we attempt to isolate the specific cell types which, when suffering from NMDA receptor hypofunction, lead to higher-order cognitive dysfunction, such as impairments in working memory. We will combine transgenic mouse technologies to remove NMDA receptors from specific cell types, and observe the resultant effects on cognitive behavior.



Faculty Research Themes

Neuroscience

School Research Themes

Neuroscience & Psychiatry



Research Opportunities

PhD, Masters by Research, Honours, Master of Biomedical Science
Graduate Research Students who are interested in joining this project will need to consider their elegibility as well as other Graduate Research requirements before contacting the supervisor of this research

View application process

Key Contact

For further information about this research, please contact a supervisor.

Department

Medicine and Radiology

Research Group / Unit / Centre

Jones Laboratory: Epilepsy and Behaviour

Research Node

Royal Melbourne Hospital