New therapies for inherited renal disease – chaperones, stem cells and other agents
- Research Opportunity
- Project Status
- Medicine and Radiology
- Royal Melbourne Hospital
|Judy Savigefirstname.lastname@example.org||8405 8823||Personal web page|
|Dongmao Wang||Personal web page|
Alport syndrome is an inherited renal disease that results in end-stage renal failure, hearing loss, and ocular abnormalities. Forty % of cases are due to missense and 40% to nonsense mutations. The aim of this study is to investigate treatments that can be used for these types of different mutations, using cell lines derived from patients. The aim is to derive the optimum dose, and to understand the mechanisms by which these agents have their effect. They will then be used in a pilot study in patient to determine the effect on the rate of deterioration in renal function.
This research project is available to PhD students to join as part of their thesis.
Please contact the supervisor to discuss your options.
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