New therapies for inherited renal disease – chaperones, stem cells and other agents

Research Opportunity
Project Status
Medicine and Radiology
Royal Melbourne Hospital
Supervisor Email Number Webpage
Judy Savige 8405 8823 Personal web page
Dongmao Wang Personal web page

Project Details

Alport syndrome is an inherited renal disease that results in end-stage renal failure, hearing loss, and ocular abnormalities. Forty % of cases are due to missense and 40% to nonsense mutations. The aim of this study is to investigate treatments that can be used for these types of different mutations, using cell lines derived from patients. The aim is to derive the optimum dose, and to understand the mechanisms by which these agents have their effect. They will then be used in a pilot study in patient to determine the effect on the rate of deterioration in renal function.

Research Opportunities

This research project is available to PhD students to join as part of their thesis.
Please contact the supervisor to discuss your options.

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Faculty Research Themes

Child Health

School Research Themes

Child Health in Medicine

Key Contact

For further information about this research, please contact a supervisor.


Medicine and Radiology

Research Group / Unit / Centre

Savige Laboratory

Research Node

Royal Melbourne Hospital