New inhibitors for mitochondrial fission protein DRP1

Research Opportunity
PhD, Masters by Research, Honours, Master of Biomedical Science
Project Status
Future
Department
Surgery
Location
St Vincent's Hospital
Supervisor Email Number Webpage
Dr Shiang (Max) Lim Personal web page
Dr Jessica Holien

Project Details

Mitochondria are dynamic organelles which continuously alter their shape by fusion (elongation) and fission (fragmentation). These processes are essential to maintain the organelle fidelity and cell viability. The mitochondrial fission protein, Drp1, has been shown to have a role in cancer and heart disease. Therefore, inhibitors of Drp1 are currently being sought as potential treatments for these diseases. Mdivi-1 is a small molecule inhibitor of Drp1 and has been shown to have a protective effect in various cellular injury models. However, Mdivi-1 is not a good drug as it has poor water solubility and lacks potency. This project aims to search for more potent Drp1 inhibitors.

The knowledge and skills involved in this project are suitable for students who are interested in drug discovery, mitochondrial biology and pharmacology. A student working on this project will have the opportunity to learn various experimental skills, including; computational drug discovery, cell culture, western blotting and histology.

This project is conducted in St Vincent’s Institute of Medical Research, Cardiac Regeneration Group, (O’Brien Institute Department of SVI).



Faculty Research Themes

Cancer

School Research Themes

Cancer in Medicine, Cardiometabolic



Research Opportunities

PhD, Masters by Research, Honours, Master of Biomedical Science Graduate Research Students who are interested in joining this project will need to consider their elegibility as well as other Graduate Research requirements before contacting the supervisor of this research

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Key Contact

For further information about this research, please contact a supervisor.

Department

Surgery

Research Node

St Vincent's Hospital