Modulation of CAMKK-Beta signalling by genetic variants

Research Opportunity
PhD, Masters by Research, Honours, Master of Biomedical Science
Project Status
Future
Department
Medicine and Radiology
Location
St Vincent's Hospital
Supervisor Email Number Webpage
Prof Bruce Kemp Personal web page

Project Details

CaMKKβ is an upstream kinase for AMPK as well as CaMKI, CaMKIV and SIRT1. It has important roles in cellular and whole body metabolism, neuronal morphology and memory formation. This project focuses on understanding how CaMKKβ is regulated by multisite phosphorylation at structural, biochemical and cellular levels.  Genetic variants of CaMKK2 have recently been linked to anxiety and schizophrenia.  We are identifying how single nucleotide polymorphisms alter CaMKK2 activity.

This project is conducted in St Vincent’s Institute of Medical Research, Protein Chemistry and Metabolism Unit.


School Research Themes

Cardiometabolic



Research Opportunities

PhD, Masters by Research, Honours, Master of Biomedical Science
Graduate Research Students who are interested in joining this project will need to consider their elegibility as well as other Graduate Research requirements before contacting the supervisor of this research

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Key Contact

For further information about this research, please contact a supervisor.

Department

Medicine and Radiology

Research Node

St Vincent's Hospital