Modulation of CAMKK-Beta signalling by genetic variants
- Research Opportunity
- PhD, Masters by Research, Honours, Master of Biomedical Science
- Project Status
- Medicine and Radiology
- St Vincent's Hospital
|Prof Bruce Kemp||Personal web page|
CaMKKβ is an upstream kinase for AMPK as well as CaMKI, CaMKIV and SIRT1. It has important roles in cellular and whole body metabolism, neuronal morphology and memory formation. This project focuses on understanding how CaMKKβ is regulated by multisite phosphorylation at structural, biochemical and cellular levels. Genetic variants of CaMKK2 have recently been linked to anxiety and schizophrenia. We are identifying how single nucleotide polymorphisms alter CaMKK2 activity.
This project is conducted in St Vincent’s Institute of Medical Research, Protein Chemistry and Metabolism Unit.
School Research Themes
PhD, Masters by Research, Honours, Master of Biomedical Science Graduate Research Students who are interested in joining this project will need to consider their elegibility as well as other Graduate Research requirements before contacting the supervisor of this research
For further information about this research, please contact a supervisor.