Understanding the microenvironment of lymphodema

Research Opportunity
PhD, Masters by Research, Honours, Master of Biomedical Science
Project Status
Future
Department
Surgery
Location
St Vincent's Hospital
Supervisor Email Number Webpage
Dr Tara Karnezis Personal web page
Dr Ramin Shayan Personal web page

Project Details

Lymphodema is a debilitating disease caused by an impairment of the lymphatic system characterised by soft tissue swelling, fat accumulation, pain and recurring infection. Approximately 20% of cancer patients undergoing radiotherapy and/or surgical resection of lymph nodes will develop Lymphodema. Communication between cells is a fundamental process during disease progression. One of the key features of lymphodema is the accumulation of fat within the surrounding tissue, fibrosis, poor immunity and extreme pain. We would like to understand how adipocytes, nerve cells, fibroblasts and immune cells communicate with lymphatic endothelial cells during the course of lymphodema. The project will involve development of genetic animal models, cell biology and cell imaging and bioinformatics to understand the communication between different cell types in affected tissue.

This project is conducted in St Vincent’s Institute of Medical Research, Lympathic and Regenerative Surgery Group, (O’Brien Institute Department of SVI).



Faculty Research Themes

Cancer

School Research Themes

Cancer in Medicine



Research Opportunities

PhD, Masters by Research, Honours, Master of Biomedical Science
Graduate Research Students who are interested in joining this project will need to consider their elegibility as well as other Graduate Research requirements before contacting the supervisor of this research

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Key Contact

For further information about this research, please contact a supervisor.

Department

Surgery

Research Node

St Vincent's Hospital