M2 Polarization of microglia as a new approach targeting temporal lobe epilepsy
- Research Opportunity
- PhD, Masters by Research, Honours
- Project Status
- Medicine and Radiology
- Royal Melbourne Hospital
|Dr. Idrish Alifirstname.lastname@example.org|
|Prof. Terence O'Brien|
Brain inflammatory is a characteristic of epileptic disorders and may promote its development and progression by affecting brain cell death, structural connectivity and excitability. The inflammatory response involves an acute classical immune activation (M1) that releases pro-inflammatory mediators promoting disease progression.
It may also involve M2 activation that mediates anti-inflammatory mechanisms promoting repair. Here, we aim to compare in an animal model of epilepsy, the seizure related outcomes between strategies to induce an M2 immune activation using genetic approaches or an overall inhibition of inflammatory response. We hypothesize that modulating the neuroinflammatory responses will be protective against development of epilepsy.
Faculty Research Themes
School Research Themes
PhD, Masters by Research, Honours Graduate Research Students who are interested in joining this project will need to consider their elegibility as well as other Graduate Research requirements before contacting the supervisor of this research
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