Intensive continuous monitoring of motor function in acute stroke: development of a broadband-based wearable motion detector (STROKE WATCH 3)

Research Opportunity
PhD, Masters by Research, Honours
Project Status
Future
Department
Medicine and Radiology
Location
Royal Melbourne Hospital
Supervisor Email Number Webpage
A/Professor Bernard Yan bernardy@unimelb.edu.au Personal web page
Professor Stephen Davis Personal web page

Project Details

Acute stroke is caused by a blockage of one of the arteries in the brain resulting in interrupted blood supply. Brain cells deprived of oxygenated blood die rapidly unless blood supply is restored. The clinical manifestation is acute loss of neurological function e.g. paralysis of arms and legs. One of the milestones of modern management of acute stroke is revascularization (either by mechanically retrieving the clot or by intravenous agents) in order to unblock the blocked artery. A proportion of patients will experience recanalization (reopening) of blocked arteries with consequent recovery of arm and leg movements (motor recovery) but about 30% will deteriorate.

The monitoring of motor recovery is by clinical observation is critical in the management of stroke patients. Patients who exhibit deterioration may benefit from urgent treatment. However, the current clinical observation paradigm is time consuming and subjected to inter-observer bias. We aim to validate the clinical utility of a novel portable motion detector (STROKE WATCH 3) which allows for continuous monitoring of motor recovery in acute stroke patients.

The findings of the study may inform future decision to mandate continuous motor monitoring of patients post thrombolysis. We envisage that the study findings may lead to investigations of the STROKE WATCH 3 system in other neurological diseases e.g. Epilepsy. BENCH TO BEDSIDE - MEDICAL RESEARCH University of Melbourne at Royal Melbourne Hospital Honours/MBiomedSc Projects 2017 64 Research Plan: Human Ethics Committee approval has been obtained.

The first phase of the project has been completed with 10 healthy controls. The second phase of the project aims to study the motor function of stroke patients. We hypothesize that the motion detector (STROKE WATCH 3) is able to better detect motor function fluctuations compared to standard clinical observations. Inclusion criteria: acute stroke patients admitted to RMH Stroke Care Unit.

Methods: study subjects will wear the STROKE WATCH system on each limb for 24 hours. Accelerometry raw data will be continuously transmitted



Faculty Research Themes

Neuroscience

School Research Themes

Neuroscience & Psychiatry



Research Opportunities

PhD, Masters by Research, Honours Graduate Research Students who are interested in joining this project will need to consider their elegibility as well as other Graduate Research requirements before contacting the supervisor of this research

Read more

Key Contact

For further information about this research, please contact a supervisor.

Department

Medicine and Radiology

Research Node

Royal Melbourne Hospital