The impact of malaria control measures on the acquisition of immunity to malaria

Research Opportunity
PhD, Masters by Research, Honours, Master of Biomedical Science
Project Status
Future
Department
Medicine and Radiology
Location
Royal Melbourne Hospital
Supervisor Email Number Webpage
Professor James Beeson Personal web page
Associate Professor Freya Fowkes Personal web page

Project Details

Malaria caused by Plasmodium falciparum remains a major cause of morbidity and mortality globally. It has decreased substantially over the past decade due to increased control measures and access to efficacious treatments. People living in these areas are less exposed to malaria over time due to declining transmission. Naturally-acquired blood-stage immunity develops to malaria after repeated exposure that controls bloodstage parasitaemia, thereby reducing clinical symptoms and life-threatening complications. Antibodies are important mediators of this acquired immunity, however it is unclear how declining malaria transmission impacts on the acquisition of malarial immunity.

The overall objective of this project is to quantify the impact of declining transmission on the acquisition of malarial immunity in a malaria endemic area of Thailand, both in the context of clinical disease and malaria transmission. Laboratory techniques will include ELISA and functional antibody assays and/or epidemiological analyses. Findings will help us understand how immunity develops and is maintained against infectious diseases in populations with declining transmission.

For all queries please contact Arzum, arzum.cubuk@burnet.edu.au



Faculty Research Themes

Infection and Immunology

School Research Themes



Research Opportunities

PhD, Masters by Research, Honours, Master of Biomedical Science
Graduate Research Students who are interested in joining this project will need to consider their elegibility as well as other Graduate Research requirements before contacting the supervisor of this research

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Key Contact

For further information about this research, please contact a supervisor.

Department

Medicine and Radiology

Research Group / Unit / Centre

Research Node

Royal Melbourne Hospital