Immunity to malaria in children and pregnant women

Research Opportunity
PhD, Masters by Research, Honours, Master of Biomedical Science
Project Status
Future
Department
Medicine and Radiology
Location
Royal Melbourne Hospital
Supervisor Email Number Webpage
Associate Professor Freya Fowkes Personal web page

Project Details

Malaria caused by the parasite Plasmodium falciparum is a leading cause of mortality and morbidity globally, particularly among young children and pregnant women. After repeated exposure, individuals develop effective immunity that controls blood-stage parasitaemia, thereby reducing clinical symptoms and life-threatening complications. Antibodies are important mediators of this acquired immunity.

Very little is known about antibody acquisition, maintenance and boosting of antibody responses with respect to exposure to parasites during childhood and pregnancy. Furthermore little is known about maternal transfer of antibodies and subsequent maternal antibody decay and infant antibody acquisition in infants born in malaria endemic areas. We have access to samples from several established longitudinal cohorts of pregnant women and children living in malaria endemic areas that can address questions of antibody acquisition and maintenance through antibody assays and epidemiological analyses. Findings will help us understand how immunity develops and is maintained against infectious diseases.

For all queries, please contact Arzum, arzum.cubuk@burnet.edu.au



Faculty Research Themes

Infection and Immunology

School Research Themes



Research Opportunities

PhD, Masters by Research, Honours, Master of Biomedical Science
Graduate Research Students who are interested in joining this project will need to consider their elegibility as well as other Graduate Research requirements before contacting the supervisor of this research

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Key Contact

For further information about this research, please contact a supervisor.

Department

Medicine and Radiology

Research Group / Unit / Centre

Research Node

Royal Melbourne Hospital