Identifying IL-17 receptor functions in pancreatic beta cells

Research Opportunity
PhD, Masters by Research, Honours, Master of Biomedical Science
Project Status
Future
Department
Medicine and Radiology
Location
St Vincent's Hospital
Supervisor Email Number Webpage
Dr Andrew Sutherland
A/Prof Helen Thomas Personal web page

Project Details

Type 1 diabetes (T1D) is a human disease involving progressive autoimmune destruction of the beta cells in the pancreatic islets. Inflammatory cytokines and lymphocytes are important inducers of T1D, however their precise mechanisms of action in T1D pathogenesis remain unclear. A clearer understanding of these processes will provide better opportunities for therapeutic intervention in human T1D patients.

Recent advances in T1D research indicate that inflammatory type 17 immune responses are involved in the pathogenesis of T1D in NOD mice and humans, thus it is likelythat type 17 immunity is a key pathogenic regulator of T1D. IL-17 family cytokines are powerful drivers of inflammation and there is increasing evidence that IL-17/IL-17 receptor signalling induces inflammatory pathways in pancreatic beta-cells and plays a pathogenic role in the development of T1D. This project aims to define novel type 17 associated pathogenic mechanisms in the context of T1D. Techniques will include use of gene deficient beta-cell lines and novel strains of knockout mice, islet isolation, immune cell transfer, histology, quantitative RT-PCR, ELISA, Western blotting and flow cytometry.

This project is conducted in St Vincent’s Institute of Medical Research, Islet Biology Unit.


School Research Themes

Cardiometabolic



Research Opportunities

PhD, Masters by Research, Honours, Master of Biomedical Science Graduate Research Students who are interested in joining this project will need to consider their elegibility as well as other Graduate Research requirements before contacting the supervisor of this research

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Key Contact

For further information about this research, please contact a supervisor.

Department

Medicine and Radiology

Research Group / Unit / Centre

Research Node

St Vincent's Hospital