How do cells overcome mitochondrial impairment in optic neuropathy?

Research Opportunity
PhD, Masters by Research, Honours, Master of Biomedical Science
Project Status
Future
Department
Surgery
Location
Surgery, Otolaryngology, Royal Victorian Eye and Ear Hospital
Supervisor Email Number Webpage
A/Prof Ian Trounce Personal web page

Project Details

The vast majority of the genetic information in cells is stored in the nucleus, but mitochondria also contain a small genome that is maternally inherited, mitochondrial DNA (mtDNA). Mutations in mtDNA that impair energy production can cause disease, and affect particularly the nervous system, including the eye, as energy available to cells is depleted. This basic science project aims to apply biochemistry and molecular biology tools to identify the protective pathways that enable cells to overcome mitochondrial dysfunction in the context of optic neuropathy. Specific techniques to be used in this project include basic cell culture, DNA extraction, PCR, protein extraction and immunoblotting. This project is available to Honours or PhD students.

This project is conducted in Centre for Eye Research Australia, Mitochondria and Neurodegeneration Group.



Faculty Research Themes

Neuroscience

School Research Themes

Neuroscience & Psychiatry



Research Opportunities

PhD, Masters by Research, Honours, Master of Biomedical Science Graduate Research Students who are interested in joining this project will need to consider their elegibility as well as other Graduate Research requirements before contacting the supervisor of this research

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Key Contact

For further information about this research, please contact a supervisor.

Department

Surgery

Research Node

Surgery, Otolaryngology, Royal Victorian Eye and Ear Hospital