Hearing loss and acidosis in the cochlea
- Research Opportunity
- PhD, Masters by Research, Honours, Master of Biomedical Science
- Project Status
- Surgery, Otolaryngology, Royal Victorian Eye and Ear Hospital
|Dr Karina Needham||Personal web page|
The auditory system is vulnerable to a number of pathological conditions (i.e. ischemia, excessive noise exposure) that cause acidification or acidosis (a drop in the extracellular pH of a cell). Exposure to extreme or prolonged acidosis is toxic to neurons. Evidence suggests that this is mediated in part by acid-sensing ion channels (ASICs), a family of proton-gated ion channels activated by extracellular acidosis and modulated by a range of signalling molecules, such as inflammatory mediators. The role of ASICs in the cochlea and in response to trauma is emerging as an important one in triggering hearing loss. This project will investigate how activation of ASICs by acidosis contributes to hearing pathologies such as sensorineural hearing loss and tinnitus.
We are using a number of experimental approaches to examine this question, including hearing assessments (electrophysiology), immunohistochemistry to characterise biochemical/neurochemical markers and synaptic proteins, tissue culture of cochlea sections, and patch-clamp recordings. This project would suit students with an interest in any of the following disciplines: physiology, neuroscience, pathology, anatomy, cell biology, pharmacology or biochemistry and molecular biology.
Faculty Research Themes
School Research Themes
PhD, Masters by Research, Honours, Master of Biomedical Science Graduate Research Students who are interested in joining this project will need to consider their elegibility as well as other Graduate Research requirements before contacting the supervisor of this research
For further information about this research, please contact a supervisor.