Good cholesterol for treatment of AMD

Research Opportunity
PhD, Masters by Research, Honours, Master of Biomedical Science
Project Status
Future
Department
Surgery
Location
Surgery, Otolaryngology, Royal Victorian Eye and Ear Hospital
Supervisor Email Number Webpage
Dr Hitesh Peshavariya Personal web page

Project Details

Hallmark features of early AMD include accumulation of lipid-rich cholesterol (bad cholesterol) termed ‘drusen’ underneath the retinal pigment epithelium (RPE), thickening of Bruch’s membrane (BM), and inflammation. There are currently no treatments to prevent the development of the early stages of AMD, nor specific interventions to prevent its progression to late AMD. However, increasing levels of high density lipoprotein (HDL) also known as “good cholesterol” has been shown to reduce the risk of the similar pathological conditions in cardiovascular diseases.

The effects of HDL on AMD are unknown. We hypothesise that reconstituted HDL (rHDL) treatment has protective effects and will slow or prevent BM thickening, inflammation and improve retinal function in mice. We explore the effects of rHDL using animal models with thickened Bruch’s membrane, lipid accumulation and inflammation. We are interested in testing the anti-inflammatory effects of rHDL in vitro using cell culture based methods.

This project is conducted in Centre for Eye Research Australia, Oxidant Signalling Group.


School Research Themes

Ageing



Research Opportunities

PhD, Masters by Research, Honours, Master of Biomedical Science Graduate Research Students who are interested in joining this project will need to consider their elegibility as well as other Graduate Research requirements before contacting the supervisor of this research

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Key Contact

For further information about this research, please contact a supervisor.

Department

Surgery

Research Node

Surgery, Otolaryngology, Royal Victorian Eye and Ear Hospital