Characterisation of GLUT12 knockout mice
- Research Opportunity
- PhD, Masters by Research, Honours, Master of Biomedical Science
- Project Status
- Medicine and Radiology
- St Vincent's Hospital
|Prof Bruce Kemp||Personal web page|
Glucose transport into skeletal muscle via facilitative glucose transporter (GLUT) proteins is a ratelimiting step in post-prandial glucose clearance. Thus, the activity of GLUT proteins is critical for whole body glucose homeostasis. Defects in the function of the insulin sensitive transporter GLUT4 are known to contribute to skeletal muscle insulin resistance. The glucose transporter GLUT12 is also expressed in skeletal muscle but its role in glucose homeostasis is unclear.
We have previously found that GLUT12-mediated glucose transport is insulin-independent and can be acutely induced by glucose and amino acids. This project aims to characterize the phenotype of GLUT12 whole-body and tissue-specific knockout mice and to investigate the physiological importance of GLUT12 for energy metabolism and glucose disposal in vivo. Furthermore, using cultured primary myoblasts, we aim to determine the molecular mechanism of glucose-induced GLUT12 expression and translocation.
These findings will increase our understanding of the role of insulin-independent glucose disposal in whole-body glucose homeostasis, which may have important implications in the context of defective insulin action, such as in obesity and Type 2 diabetes.
This project is conducted in St Vincent’s Institute of Medical Research, Protein Chemistry and Metabolism Unit.
School Research Themes
PhD, Masters by Research, Honours, Master of Biomedical Science Graduate Research Students who are interested in joining this project will need to consider their elegibility as well as other Graduate Research requirements before contacting the supervisor of this research
For further information about this research, please contact a supervisor.