Understanding the genetic basis of lipedema

Research Opportunity
PhD, Masters by Research, Honours, Master of Biomedical Science
Project Status
Future
Department
Surgery
Location
St Vincent's Hospital
Supervisor Email Number Webpage
Dr Tara Karnezis Personal web page
Dr Ramin Shayan Personal web page

Project Details

Lipidema is a debilitating disease caused by excessive accumulation of fat in arms and lower extremities, affecting women at the onset of puberty. There is no known cure. Often, there is a lymphodema component associated with this disease but the precise role of lymphatics in disease pathology is unclear. This project will initiate a genetic screen of affected individuals and their families in order to identify genes that may be affected in these patients. This project will utilise microarray platforms, immunohistochemistry of human specimens, metabolomics, bioinformatics and the generation of animal models using CRISPR technology to determine whether there is a mutation within a specific gene of affected individuals that leads to Lipidema.

This project is conducted in St Vincent’s Institute of Medical Research, Lympathic and Regenerative Surgery Group, (O’Brien Institute Department of SVI).


School Research Themes

Women's Health



Research Opportunities

PhD, Masters by Research, Honours, Master of Biomedical Science Graduate Research Students who are interested in joining this project will need to consider their elegibility as well as other Graduate Research requirements before contacting the supervisor of this research

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Key Contact

For further information about this research, please contact a supervisor.

Department

Surgery

Research Node

St Vincent's Hospital