Gene signatures of the ‘lymphaticome’

Research Opportunity
PhD, Masters by Research, Honours, Master of Biomedical Science
Project Status
Future
Department
Surgery
Location
St Vincent's Hospital
Supervisor Email Number Webpage
Dr Tara Karnezis Personal web page
Dr Ramin Shayan Personal web page

Project Details

The lymphatic system is a hierarchical system- comprised of lymphatic endothelial cells-that is integral to fluid homeostasis, absorption of dietary fat and immune cell surveillance. The lymphatic system can be hijacked during cancer to promote metastasis to distant organ sites and a dysfunctional lymphatic system can lead to debilitating a disease such as Lymphodema, the swelling of soft tissue often in the extremities. Lymphatic vessels are present in most organ tissues such as skin, liver, kidney, pancreas, heart, digestive tract, lymphoid organs and more recently, discovered in the brain. The nature and morphology of lymphatics would therefore reflect their function within a given organ system. We would like to gain an understanding of the genetic signatures of the “lymphaticome”. This information will allow for a greater understanding of the lymphatic system and diseases relating to it and provide an avenue to develop organ specific therapeutics. The project will develop skills in cell purification and cell biology, FACs, microarray, bioinformatics and animal models of disease.

This project is conducted in St Vincent’s Institute of Medical Research, Lympathic and Regenerative Surgery Group, (O’Brien Institute Department of SVI).


School Research Themes

Cardiometabolic , Neuroscience & Psychiatry



Research Opportunities

PhD, Masters by Research, Honours, Master of Biomedical Science
Graduate Research Students who are interested in joining this project will need to consider their elegibility as well as other Graduate Research requirements before contacting the supervisor of this research

View application process

Key Contact

For further information about this research, please contact a supervisor.

Department

Surgery

Research Node

St Vincent's Hospital