Elucidating molecular signalling pathways controlled by anti-inflammatory steroids

Research Opportunity
PhD, Masters by Research, Honours
Project Status
Medicine and Radiology
Royal Melbourne Hospital
Supervisor Email Number Webpage
Dr. Adrian Achuthan aaa@unimelb.edu.au Personal web page

Project Details

Steroids (glucocorticoids) are widely used to treat the chronic inflammation and pain associated with many diseases such as rheumatoid arthritis and osteoarthritis. Unfortunately, there are side effects associated with usage of glucocorticoids in such diseases.

In this project you will use genome-wide approaches such as microarray to indentify the genes that are regulated by glucocorticoids. More specifically you will investigate molecular signalling pathways that lead to activation of transcription factors that lead to differential expression of glucocoritcoid-controlled genes in inflammatory conditions. Enhancing our understanding of molecular signalling pathways that are governed by glucocorticoids may lead to improved clinical therapies with minimal side effects.

Research Opportunities

This research project is available to PhD, Masters by Research, Honours students to join as part of their thesis.
Please contact the supervisor to discuss your options.

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Faculty Research Themes

Infection and Immunology

School Research Themes


Key Contact

For further information about this research, please contact a supervisor.


Medicine and Radiology

Research Node

Royal Melbourne Hospital