Dissecting the relevance of a novel molecular pathway in stem cells and immunodeficiencies

Research Opportunity
PhD, Masters by Research, Honours, Master of Biomedical Science
Project Status
Future
Department
Medicine and Radiology
Location
St Vincent's Hospital
Supervisor Email Number Webpage
Dr Mark Chong Personal web page

Project Details

We have found that Drosha, one of the RNase III enzymes necessary for microRNA biogenesis, also functions to regulate the stability of certain protein-coding mRNAs. This occurs via recognition and cleavage of secondary stem-loop structures within these mRNAs. We have found that this activity is largely restricted to and critical for the function of stem cells. In particular, we showed that Drosha-mediated mRNA cleavage is required in haematopoietic stem cells for the differentiation of myeloid lineages (dendritic cells, monocytes, granulocytes, etc).

Furthermore, we believe that defects in this pathway contribute to certain diseases of the haematopoietic system, particularly myelodysplastic syndrome. The goal of this project is to understand how this mRNA cleavage mechanism is regulated in stem cells and its potential involvement in haematopoietic diseases. This will involve the analysis of various genetically modified mouse models, and will employ a range of genomic, molecular and cellular techniques.

This project is conducted in St Vincent’s Institute of Medical Research, Genomics and Immunology Laboratory.



Faculty Research Themes

Infection and Immunology

School Research Themes

Cancer in Medicine



Research Opportunities

PhD, Masters by Research, Honours, Master of Biomedical Science Graduate Research Students who are interested in joining this project will need to consider their elegibility as well as other Graduate Research requirements before contacting the supervisor of this research

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Key Contact

For further information about this research, please contact a supervisor.

Department

Medicine and Radiology

Research Group / Unit / Centre

Research Node

St Vincent's Hospital