Dissecting genomic and transcriptional complexities underlying immune competence and immune diseases
- Research Opportunity
- PhD, Masters by Research, Honours, Master of Biomedical Science
- Project Status
- Medicine and Radiology
- St Vincent's Hospital
|Dr Mark Chong||Personal web page|
Mammalian genomes contain approximately 20,000 genes. This is only twice the number of genes found in simple organisms such as worms and flies, and half the number of some plants such as potatoes. How is it then possible to achieve the complexity of humans and other mammals with this few genes? One possibility is the derivation of multiple products from each gene. Different gene products can be achieved during transcription by exon skipping or alternate exon usage. The exclusion or inclusion of different exons from a messenger RNA can result in altered protein coding potential and/or regulatory properties. Thus, the number of potential gene products is far greater than 20,000. Furthermore, the utilisation of different regulatory elements (promoters, enhancer, silencers, etc) facilitates complex temporal and tissue-specific gene regulation. This project will investigate the role of such complexities in the development of T cells of the immune system. We also postulate that defects in appropriate splicing and/or gene regulation underlie many diseases of the immune system, such as autoimmunity, immune deficiency or haematopoietic cancers.
This project will investigate these possibilities, and will involve the application of various techniques, including next generation sequencing and other genomic approaches, animal models, and a range of molecular biology and immunology techniques.
This project is conducted in St Vincent’s Institute of Medical Research, Genomics and Immunology Laboratory.
This research project is available to PhD, Masters by Research, Honours, Master of Biomedical Science students to join as part of their thesis.
Please contact the supervisor to discuss your options.
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