Development of regenerative therapy for photoreceptor losses using cellular reprogramming technology

Research Opportunity
PhD, Masters by Research, Honours, Master of Biomedical Science
Project Status
Future
Department
Surgery
Location
Surgery, Otolaryngology, Royal Victorian Eye and Ear Hospital
Supervisor Email Number Webpage
Dr Raymond Wong Personal web page

Project Details

The loss of photoreceptors in many degenerative eye diseases such as retinitis pigmentosa (RP) which affects >1 million people worldwide is a leading cause of blindness. Currently, there are no effective treatments to cure blindness once photoreceptors are lost. An important feature in RP is that despite the loss of photoreceptors, the other inner retinal neuronal structures and visual pathway remain largely intact. Therefore, photoreceptor regeneration has the very real prospect of restoring vision in RP patients.

Recent advances in cellular reprogramming allow the conversion of one somatic cell type directly into another using master transcription factors. This project aims to develop cellular reprogramming technology to convert and repurpose residing retinal cells into new photoreceptors using the CRISPR activation system. Importantly, this approach would provide a novel regenerative therapy approach to treat photoreceptor loss without the complications of transplantation.

This project is conducted in Centre for Eye Research Australia, Cellular Programming Group.



Faculty Research Themes

Neuroscience

School Research Themes

Neuroscience & Psychiatry



Research Opportunities

PhD, Masters by Research, Honours, Master of Biomedical Science
Graduate Research Students who are interested in joining this project will need to consider their elegibility as well as other Graduate Research requirements before contacting the supervisor of this research

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Key Contact

For further information about this research, please contact a supervisor.

Department

Surgery

Research Group / Unit / Centre

Research Node

Surgery, Otolaryngology, Royal Victorian Eye and Ear Hospital