Developing new assays to identify mechanisms of human immunity to malaria
- Research Opportunity
- PhD, Masters by Research, Honours, Master of Biomedical Science
- Project Status
- Medicine and Radiology
- Royal Melbourne Hospital
|Professor James Beeson||Personal web page|
|Dr Philippe Boeuf||Personal web page|
Malaria caused by Plasmodium falciparum is a leading cause of mortality and morbidity globally, particularly among young children. After repeated exposure, individuals develop effective immunity that controls blood-stage parasitaemia, thereby reducing clinical symptoms and life-threatening complications.
Antibodies are important mediators of this acquired immunity. The demonstration that naturally-acquired antibodies are associated with protection from malaria is one of the criteria used to objectively prioritize malaria antigens for malaria vaccine development. This project will focus on developing new assays to identify the antibody-dependent mechanisms that mediate protective immunity against malaria. This knowledge is crucial for the development of effective vaccines against malaria.
The project may combine detailed studies of immune responses with clinical and population studies in Africa, Asia, and Papua New Guinea. It will examine how immune responses protect individuals from malaria; especially how antibodies interact with immune cells to neutralize and clear malaria parasites in the blood.
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Faculty Research Themes
School Research Themes
PhD, Masters by Research, Honours, Master of Biomedical Science Graduate Research Students who are interested in joining this project will need to consider their elegibility as well as other Graduate Research requirements before contacting the supervisor of this research
For further information about this research, please contact a supervisor.