Developing new assays to identify mechanisms of human immunity to malaria

Research Opportunity
PhD, Masters by Research, Honours, Master of Biomedical Science
Project Status
Future
Department
Medicine and Radiology
Location
Royal Melbourne Hospital
Supervisor Email Number Webpage
Professor James Beeson Personal web page
Dr Philippe Boeuf Personal web page

Project Details

Malaria caused by Plasmodium falciparum is a leading cause of mortality and morbidity globally, particularly among young children. After repeated exposure, individuals develop effective immunity that controls blood-stage parasitaemia, thereby reducing clinical symptoms and life-threatening complications.

Antibodies are important mediators of this acquired immunity. The demonstration that naturally-acquired antibodies are associated with protection from malaria is one of the criteria used to objectively prioritize malaria antigens for malaria vaccine development. This project will focus on developing new assays to identify the antibody-dependent mechanisms that mediate protective immunity against malaria. This knowledge is crucial for the development of effective vaccines against malaria.

The project may combine detailed studies of immune responses with clinical and population studies in Africa, Asia, and Papua New Guinea. It will examine how immune responses protect individuals from malaria; especially how antibodies interact with immune cells to neutralize and clear malaria parasites in the blood.

For all queries please contact Arzum, arzum.cubuk@burnet.edu.au

Research Opportunities

This research project is available to PhD, Masters by Research, Honours, Master of Biomedical Science students to join as part of their thesis.
Please contact the supervisor to discuss your options.

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Faculty Research Themes

Infection and Immunology

School Research Themes



Key Contact

For further information about this research, please contact a supervisor.

Department

Medicine and Radiology

Research Group / Unit / Centre

Research Node

Royal Melbourne Hospital