World-wide data-sharing to detect neurobiological alterations in MDD: the worldwide ENIGMA Major Depressive Disorder consortium

Research Opportunity
PhD, Masters by Research, Honours, Master of Biomedical Science
Project Status
Supervisor Email Number Webpage
Lianne Schmaal

Project Details

Major depressive disorder (MDD) is a highly debilitating disorder that has an enormous detrimental impact on patient's life and a high social and economic burden. Many studies have identified structural and functional brain alterations in MDD. However, to date, volumetric and functional brain differences have not always been consistent, which may in part be explained by small sample sizes and differences in methodological and clinical characteristics between studies.

To address the limited statistical power of prior studies, the MDD working group within the “Enhancing NeuroImaging Genetics through Meta-Analysis”, or ENIGMA, was initiated a few years ago, see The overall aim of the ENIGMA MDD consortium is to establish the neurobiological correlates underlying variation in disease profile and disease course. Currently, 31 research sites from around the world are participating in ENIGMA MDD and share neuroimaging data from >8,000 healthy controls and >2,500 MDD patients. The student will support ongoing ENIGMA MDD work, which includes development and execution of data processing, quality assurance and statistical analyses protocols for neuroimaging (structural MRI, resting state fMRI and DTI), organising and harmonising databases, communicating with members of the consortium across the world, writing scientific papers on the above topics, and incorporating the research into a PhD thesis.

Candidates with an interest in psychology, biological psychiatry and imaging neuroscience are encouraged to apply. Having prior experience with neuroimaging analyses and having strong statistical and computer programming skills is desirable. Further detail about this project is available upon request.

Faculty Research Themes


School Research Themes

Neuroscience & Psychiatry

Research Opportunities

PhD, Masters by Research, Honours, Master of Biomedical Science Graduate Research Students who are interested in joining this project will need to consider their elegibility as well as other Graduate Research requirements before contacting the supervisor of this research

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Research Group / Unit / Centre