Controlled mechanical stimulation for cartilage regeneration modelling with 3D bioprinting techniques

Research Opportunity
PhD, Masters by Research
Project Status
Future
Department
Surgery
Location
St Vincent's Hospital
Supervisor Email Number Webpage
Dr Serena Duchi Personal web page
Dr Carmine Onofrillo Personal web page

Project Details

Promising treatment options of cartilage injuries combine the use of 3D-printed biomaterials with stem cells, commonly referred to as bioscaffolds, to produce hyaline cartilage. Although this repair strategy has good prospects, its main shortcomings are the difficulty in matching and mimicking cartilage development in the in vitro studies required to validate the specific 3D bioprinting system.

The aim of this project is to characterize the rate of chondrogenic differentiation of 3D bioprinted samples laden with mesenchymal stem cells, by mechanical stimulation. We aim to demonstrate that the mechanical loading mimics the physiological development environment of native cartilage and allows regeneration of functional cartilage.

To accomplish this goal, a specific device to dynamically load and stimulate the bioprinted scaffolds will be employed and different parameters of stimulation will be testes and validated through immunological and molecular assays.

This project is suited for a Master/PhD research project.

This project will provide opportunity for the student to take part in a discovery project embedded in a multidisciplinary team based at the 3DBioFab@ACMD, St.Vincent Hospital, Melbourne.

The candidate will acquire expertise in 3D bioprinting and mechanical bioengineering.


School Research Themes

Musculoskeletal



Research Opportunities

PhD, Masters by Research Graduate Research Students who are interested in joining this project will need to consider their elegibility as well as other Graduate Research requirements before contacting the supervisor of this research

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Key Contact

For further information about this research, please contact a supervisor.

Department

Surgery

Research Node

St Vincent's Hospital