Cell death regulation in B cell immunity and B cell lymphona

Research Opportunity
PhD, Masters by Research, Honours, Master of Biomedical Science
Project Status
Future
Department
Medicine and Radiology
Location
St Vincent's Hospital
Supervisor Email Number Webpage
A/Prof Jorg Heierhorst

Project Details

Antibody-producing B cells play crucial roles in the immune response. B cell numbers are normally tightly controlled to ensure that sufficient immune response, to eliminate auto-reactive (auto-immune) cells and to prevent the transformation of aberrant cells to malignant B cell cancers (lymphomas). B cell numbers are mainly controlled through killing of defective or superfluous cells, but how the responsible “apoptotic” cell death programs are regulated remains poorly understood.

We recently found that the transcription factor ASCIZ and its target gene Dynll1 regulate the B cell numbers by controlling the activity of the pro-apoptotic protein BIM. The aim of this new project is to determine how important BIM - and its regulation by ASCIZ and DYNLL1 - is for the generation of new B cells in the bone marrow and for the longevity of mature B cells in the spleen and lymphnodes of mice, and how this contributes to normal immune responses and the development of B cell lymphoma.

Students will be able to learn a wide range of modern molecular biology, cell biology and genetics approaches, including DNA and protein analyses and flow cytometry (FACS).

This project is conducted in St Vincent’s Institute of Medical Research, Molecular Genetics Unit.



Faculty Research Themes

Cancer, Infection and Immunology

School Research Themes

Cancer in Medicine



Research Opportunities

PhD, Masters by Research, Honours, Master of Biomedical Science Graduate Research Students who are interested in joining this project will need to consider their elegibility as well as other Graduate Research requirements before contacting the supervisor of this research

Read more

Key Contact

For further information about this research, please contact a supervisor.

Department

Medicine and Radiology

Research Node

St Vincent's Hospital