Cell death regulation in B cell immunity and B cell lymphona
- Research Opportunity
- PhD, Masters by Research, Honours, Master of Biomedical Science
- Project Status
- Medicine and Radiology
- St Vincent's Hospital
|A/Prof Jorg Heierhorst|
Antibody-producing B cells play crucial roles in the immune response. B cell numbers are normally tightly controlled to ensure that sufficient immune response, to eliminate auto-reactive (auto-immune) cells and to prevent the transformation of aberrant cells to malignant B cell cancers (lymphomas). B cell numbers are mainly controlled through killing of defective or superfluous cells, but how the responsible “apoptotic” cell death programs are regulated remains poorly understood.
We recently found that the transcription factor ASCIZ and its target gene Dynll1 regulate the B cell numbers by controlling the activity of the pro-apoptotic protein BIM. The aim of this new project is to determine how important BIM - and its regulation by ASCIZ and DYNLL1 - is for the generation of new B cells in the bone marrow and for the longevity of mature B cells in the spleen and lymphnodes of mice, and how this contributes to normal immune responses and the development of B cell lymphoma.
Students will be able to learn a wide range of modern molecular biology, cell biology and genetics approaches, including DNA and protein analyses and flow cytometry (FACS).
This project is conducted in St Vincent’s Institute of Medical Research, Molecular Genetics Unit.
This research project is available to PhD, Masters by Research, Honours, Master of Biomedical Science students to join as part of their thesis.
Please contact the supervisor to discuss your options.
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