Cardioprotection with Nano-MDIVI-1

Research Opportunity
PhD, Masters by Research, Honours, Master of Biomedical Science
Project Status
Future
Department
Surgery
Location
St Vincent's Hospital
Supervisor Email Number Webpage
Dr Shiang (Max) Lim Personal web page

Project Details

Despite significant therapeutic advances, heart attack remains the leading cause of death worldwide and new therapeutic strategies are needed. Mitochondrial shape change (fusion or fission) allows them to maintain their integrity and efficient bioenergetics of the organelle, as well as influencing cell survival. Inhibiting mitochondrial fission with a small molecule, Mdivi-1, has been shown to protect from acute heart attack. We have recently developed a nanoparticle formulation of Mdivi-1 and this project aims to investigate the long-term cardioprotective effect of this new drug.

A student working on this project will have the opportunity to learn various experimental skills, including microsurgery to induce myocardial infarction in small animals, echocardiography, primary cell isolation and culture, western blotting, RTPCR and histology.

This project is conducted in St Vincent’s Institute of Medical Research, Cardiac Regeneration Group, (O’Brien Institute Department of SVI).


School Research Themes

Cardiometabolic



Research Opportunities

PhD, Masters by Research, Honours, Master of Biomedical Science Graduate Research Students who are interested in joining this project will need to consider their elegibility as well as other Graduate Research requirements before contacting the supervisor of this research

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Key Contact

For further information about this research, please contact a supervisor.

Department

Surgery

Research Node

St Vincent's Hospital