Cardioprotection with Nano-MDIVI-1
- Research Opportunity
- PhD, Masters by Research, Honours, Master of Biomedical Science
- Project Status
- St Vincent's Hospital
|Dr Shiang (Max) Lim||Personal web page|
Despite significant therapeutic advances, heart attack remains the leading cause of death worldwide and new therapeutic strategies are needed. Mitochondrial shape change (fusion or fission) allows them to maintain their integrity and efficient bioenergetics of the organelle, as well as influencing cell survival. Inhibiting mitochondrial fission with a small molecule, Mdivi-1, has been shown to protect from acute heart attack. We have recently developed a nanoparticle formulation of Mdivi-1 and this project aims to investigate the long-term cardioprotective effect of this new drug.
A student working on this project will have the opportunity to learn various experimental skills, including microsurgery to induce myocardial infarction in small animals, echocardiography, primary cell isolation and culture, western blotting, RTPCR and histology.
This project is conducted in St Vincent’s Institute of Medical Research, Cardiac Regeneration Group, (O’Brien Institute Department of SVI).
School Research Themes
PhD, Masters by Research, Honours, Master of Biomedical Science Graduate Research Students who are interested in joining this project will need to consider their elegibility as well as other Graduate Research requirements before contacting the supervisor of this research
For further information about this research, please contact a supervisor.