Bioenergetics in the optic nerve
- Research Opportunity
- PhD, Masters by Research, Honours, Master of Biomedical Science
- Project Status
- Surgery, Otolaryngology, Royal Victorian Eye and Ear Hospital
|Dr Peter van Wijngaarden||Personal web page|
Glaucoma is a neurodegenerative disease, strongly associated with ageing and high intraocular pressure. Recent work has suggested that metabolism and energy supply in the retinal ganglion cells may also play a critical role. In the optic nerve, energy is supplied to neurons by oligodendrocytes (through the intercellular transport of lactate). While it is known that this relationship is important for nerve health, little is known about how it changes with age or during periods of stress.
This project will determine how optic nerve energy supply changes with age and high intraocular pressure. Additionally, using pharmacological and genetic manipulations to block lactate transport in animal models of glaucoma, this project will investigate if perturbation of energy supply predisposes the optic nerve to damage.
This project is conducted in Centre for Eye Research Australia, Diabetic Retinopathy and Neuroglial Interactions Group.
Faculty Research Themes
School Research Themes
PhD, Masters by Research, Honours, Master of Biomedical Science Graduate Research Students who are interested in joining this project will need to consider their elegibility as well as other Graduate Research requirements before contacting the supervisor of this research
For further information about this research, please contact a supervisor.