Bioenergetics in the optic nerve

Research Opportunity
PhD, Masters by Research, Honours, Master of Biomedical Science
Project Status
Future
Department
Surgery
Location
Surgery, Otolaryngology, Royal Victorian Eye and Ear Hospital
Supervisor Email Number Webpage
Dr Peter van Wijngaarden Personal web page

Project Details

Glaucoma is a neurodegenerative disease, strongly associated with ageing and high intraocular pressure. Recent work has suggested that metabolism and energy supply in the retinal ganglion cells may also play a critical role. In the optic nerve, energy is supplied to neurons by oligodendrocytes (through the intercellular transport of lactate). While it is known that this relationship is important for nerve health, little is known about how it changes with age or during periods of stress.

This project will determine how optic nerve energy supply changes with age and high intraocular pressure. Additionally, using pharmacological and genetic manipulations to block lactate transport in animal models of glaucoma, this project will investigate if perturbation of energy supply predisposes the optic nerve to damage.

This project is conducted in Centre for Eye Research Australia, Diabetic Retinopathy and Neuroglial Interactions Group.



Faculty Research Themes

Neuroscience

School Research Themes

Neuroscience & Psychiatry, Ageing



Research Opportunities

PhD, Masters by Research, Honours, Master of Biomedical Science
Graduate Research Students who are interested in joining this project will need to consider their elegibility as well as other Graduate Research requirements before contacting the supervisor of this research

View application process

Key Contact

For further information about this research, please contact a supervisor.

Department

Surgery

Research Node

Surgery, Otolaryngology, Royal Victorian Eye and Ear Hospital