AMPK regulation of lipid metabolism

Research Opportunity
PhD, Masters by Research, Honours, Master of Biomedical Science
Project Status
Future
Department
Medicine and Radiology
Location
St Vincent's Hospital
Supervisor Email Number Webpage
Prof Bruce Kemp Personal web page

Project Details

AMPK phosphorylates and inhibits acetyl-CoA carboxylase (ACC) isoforms 1 and 2, key mediators of fatty acid metabolism. We have generated single and double knock-in mouse lines with Ser to Ala mutations for the individual AMPK phosphorylation sites on ACC 1 and 2 (Ser79Ala). These mice can no longer control cellular malonyl-CoA concentrations in response to AMPK signaling, nor do they respond to metformin when placed on a high fat diet. The project will aim to further characterize phenotypic changes associated with ACC knock in mice.

This project is conducted in St Vincent’s Institute of Medical Research, Protein Chemistry and Metabolism Unit.


School Research Themes

Cardiometabolic



Research Opportunities

PhD, Masters by Research, Honours, Master of Biomedical Science
Graduate Research Students who are interested in joining this project will need to consider their elegibility as well as other Graduate Research requirements before contacting the supervisor of this research

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Key Contact

For further information about this research, please contact a supervisor.

Department

Medicine and Radiology

Research Node

St Vincent's Hospital