AMPK regulation of lipid metabolism
- Research Opportunity
- PhD, Masters by Research, Honours, Master of Biomedical Science
- Project Status
- Medicine and Radiology
- St Vincent's Hospital
|Prof Bruce Kemp||Personal web page|
AMPK phosphorylates and inhibits acetyl-CoA carboxylase (ACC) isoforms 1 and 2, key mediators of fatty acid metabolism. We have generated single and double knock-in mouse lines with Ser to Ala mutations for the individual AMPK phosphorylation sites on ACC 1 and 2 (Ser79Ala). These mice can no longer control cellular malonyl-CoA concentrations in response to AMPK signaling, nor do they respond to metformin when placed on a high fat diet. The project will aim to further characterize phenotypic changes associated with ACC knock in mice.
This project is conducted in St Vincent’s Institute of Medical Research, Protein Chemistry and Metabolism Unit.
School Research Themes
PhD, Masters by Research, Honours, Master of Biomedical Science Graduate Research Students who are interested in joining this project will need to consider their elegibility as well as other Graduate Research requirements before contacting the supervisor of this research
For further information about this research, please contact a supervisor.