AMPK regulation of cholesterol metabolism

Research Opportunity
PhD, Masters by Research, Honours, Master of Biomedical Science
Project Status
Future
Department
Medicine and Radiology
Location
St Vincent's Hospital
Supervisor Email Number Webpage
Prof Bruce Kemp Personal web page

Project Details

Imbalance of cholesterol metabolism may contribute to the development of metabolism diseases such as hypercholesterolemia, obesity and Type 2 diabetes. It has been shown that AMPK phosphorylates HMG-CoA reductase (HMGR) on Ser 871 and inhibits the mevalonate pathway important for cholesterol synthesis.

Although early studies have shown that AMPK may play a role in cholesterol metabolism; in vivo evidence supporting this notion remains lacking.

Using HMGR S871A knock-in mice generated in the lab, this project aims to evaluate the impact of blocking AMPK-HMGR signaling on cholesterol, fat and glucose metabolism. This research will not only help to get more mechanistic insights into the etiology of metabolic diseases, but also contribute to the precise understanding of AMPK-HMGR signaling in the regulation of cholesterol, fat and glucose metabolism.

This project is conducted in St Vincent’s Institute of Medical Research, Protein Chemistry and Metabolism Unit.


School Research Themes

Cardiometabolic



Research Opportunities

PhD, Masters by Research, Honours, Master of Biomedical Science
Graduate Research Students who are interested in joining this project will need to consider their elegibility as well as other Graduate Research requirements before contacting the supervisor of this research

View application process

Key Contact

For further information about this research, please contact a supervisor.

Department

Medicine and Radiology

Research Node

St Vincent's Hospital