AMPK regulation of cholesterol metabolism
- Research Opportunity
- PhD, Masters by Research, Honours, Master of Biomedical Science
- Project Status
- Medicine and Radiology
- St Vincent's Hospital
|Prof Bruce Kemp||Personal web page|
Imbalance of cholesterol metabolism may contribute to the development of metabolism diseases such as hypercholesterolemia, obesity and Type 2 diabetes. It has been shown that AMPK phosphorylates HMG-CoA reductase (HMGR) on Ser 871 and inhibits the mevalonate pathway important for cholesterol synthesis.
Although early studies have shown that AMPK may play a role in cholesterol metabolism; in vivo evidence supporting this notion remains lacking.
Using HMGR S871A knock-in mice generated in the lab, this project aims to evaluate the impact of blocking AMPK-HMGR signaling on cholesterol, fat and glucose metabolism. This research will not only help to get more mechanistic insights into the etiology of metabolic diseases, but also contribute to the precise understanding of AMPK-HMGR signaling in the regulation of cholesterol, fat and glucose metabolism.
This project is conducted in St Vincent’s Institute of Medical Research, Protein Chemistry and Metabolism Unit.
School Research Themes
PhD, Masters by Research, Honours, Master of Biomedical Science Graduate Research Students who are interested in joining this project will need to consider their elegibility as well as other Graduate Research requirements before contacting the supervisor of this research
For further information about this research, please contact a supervisor.