A non-cytotoxic approach to reduce ocular fibrosis
- Research Opportunity
- PhD, Masters by Research, Honours, Master of Biomedical Science
- Project Status
- Surgery, Otolaryngology, Royal Victorian Eye and Ear Hospital
|Dr Hitesh Peshavariya||Personal web page|
Chemical eye injuries are a condition of ophthalmic emergency that can produce extensive damage to the ocular surface and anterior segment of the eye and can lead to vision impairment. Early diagnosis and effective treatment can ensure best possible outcomes for this potentially blinding condition. The first-line treatment typically comprises antioxidant vitamin C and topical steroid application to reduce inflammation and scarring. However, serious injuries often require longer treatment using these agents, which can cause corneal thinning and perforation.
This project aims to investigate the post-operative/injury ocular scar formation by understanding the involvement of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase-associated pathways in reactive oxygen species (ROS) production in post-surgical/injury ocular fibrosis. The ultimate aim is to improve long-term success of ocular surgery and prevent or treat post-traumatic ocular scar formation and vision loss in the patients.
This project is conducted in Centre for Eye Research Australia, Oxidant Signalling Group.
School Research Themes
PhD, Masters by Research, Honours, Master of Biomedical Science Graduate Research Students who are interested in joining this project will need to consider their elegibility as well as other Graduate Research requirements before contacting the supervisor of this research
For further information about this research, please contact a supervisor.