A non-cytotoxic approach to reduce ocular fibrosis

Research Opportunity
PhD, Masters by Research, Honours, Master of Biomedical Science
Project Status
Future
Department
Surgery
Location
Surgery, Otolaryngology, Royal Victorian Eye and Ear Hospital
Supervisor Email Number Webpage
Dr Hitesh Peshavariya Personal web page

Project Details

Chemical eye injuries are a condition of ophthalmic emergency that can produce extensive damage to the ocular surface and anterior segment of the eye and can lead to vision impairment. Early diagnosis and effective treatment can ensure best possible outcomes for this potentially blinding condition. The first-line treatment typically comprises antioxidant vitamin C and topical steroid application to reduce inflammation and scarring. However, serious injuries often require longer treatment using these agents, which can cause corneal thinning and perforation.

This project aims to investigate the post-operative/injury ocular scar formation by understanding the involvement of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase-associated pathways in reactive oxygen species (ROS) production in post-surgical/injury ocular fibrosis. The ultimate aim is to improve long-term success of ocular surgery and prevent or treat post-traumatic ocular scar formation and vision loss in the patients.
This project is conducted in Centre for Eye Research Australia, Oxidant Signalling Group.


School Research Themes

Ageing



Research Opportunities

PhD, Masters by Research, Honours, Master of Biomedical Science Graduate Research Students who are interested in joining this project will need to consider their elegibility as well as other Graduate Research requirements before contacting the supervisor of this research

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Key Contact

For further information about this research, please contact a supervisor.

Department

Surgery

Research Node

Surgery, Otolaryngology, Royal Victorian Eye and Ear Hospital