Ubiquitination and Fanconi Anemia
- Research Opportunity
- PhD, Masters by Research, Honours, Master of Biomedical Science
- Project Status
- Medicine and Radiology
- St Vincent's Hospital
|Dr Andrew Deans||Personal web page|
Ubiquitin is a small protein that is covalently attached to proteins to alter their function. In the cancer predisposition disorder Fanconi anemia, defective FANCA some how causes the attachment of ubiquitin to FANCD2 to fail. This apparently simple defect results in phenotypes of bone marrow failure, developmental problems and increased rates of leukaemia and solid tumours.
We have developed a biochemical system to study this important ubiquitination reaction. This project aims to test the biochemical mechanism by which this ubiquitination occurs, and how FANCA protein works in the reaction. A combination of approaches using the latest technologies will also test how patient associated mutations in FANCA cause Fanconi Anaemia. This will be combined with cell-based assays investigating the mechanism by which defects in ubiquitination lead to leukaemia predisposition.
This project is conducted in St Vincent’s Institute of Medical Research, Genome Stability Unit.
This research project is available to PhD, Masters by Research, Honours, Master of Biomedical Science students to join as part of their thesis.
Please contact the supervisor to discuss your options.