Towards a biological geriatric assessment
- Research Opportunity
- PhD, Masters by Research, Honours, Master of Biomedical Science
- Project Status
- Medicine and Radiology
- Royal Melbourne Hospital
|Professor Andrea Maierfirstname.lastname@example.org||+ 61383872137||Personal web page|
|Dr Camilla Tuttle|
In current geriatric practice, patients are assessed by use of the comprehensive geriatric assessment (CGA) evaluating the functional, mental and social state of the aged patient using predominantly subjective, not well defined tools. The consequence is that CGAs are not comparable and that the causal mechanisms of the geriatric condition remain unidentified. The aim is to refine the CGA and define the biological basis of geriatric conditions to eventually introduce a standardized biological geriatric assessment (BGA) being predictive for relevant outcomes and sensitive and specific for change over time. The BGA will be based on the nine molecular hallmarks of aging currently recognized.
This PhD project will investigate the role of the molecular hallmarks of ageing in age-related disease pathology in different populations (healthy to diseased). In the first two years, the PhD candidate will investigate the association of hallmarks of ageing with disease pathology combining molecular and epidemiological techniques, followed by validation of (parts of the) BGA in diseased populations.
@AgeMelbourne Research Group, led by Professor Andrea Maier, conducts innovative, translational and multi-disciplinary research in Gerontology and Biogerontology. The group's mission is to prolong the healthy lifespan of an individual by the prevention of age-related diseases. Ageing is the major risk factor of age-related diseases resulting in multimorbidity of the majority of the population aged 60 years and over. Understanding the basis of the human ageing process and its influence on age-related diseases is the starting point for establishing targeted interventions. @AgeMelbourne is currently conducting four large, longitudinal, studies examining the clinical and biological phenotypes of geriatric populations in inpatient and outpatient settings. All @AgeMelbourne studies demonstrate a strong translational component that is, improving diagnostics and therapies for age-related diseases based on a solid methodological and biological understanding. The @AgeMelbourne Research Group includes an internationally-recognised and dedicated team of academic research staff and students with a diverse background of clinical research skills and knowledge, making it an exciting and inspiring group to work with.
- Undergraduate education in science, statistics, biostatistics or epidemiology
- First Class Honours in a discipline relevant to the Research Scope
- Competitive academic track record
- Strong interest in academic research
- Capacity to work independently as a part of a research group Desirable Criteria
- Basic laboratory experience particular in regards to processing specimens and cell culturing.
- Statistical Experience
@Age Melbourne Postgraduate Research Scholarship is equivalent to APA rate (AU$ 26,288 per annum). A waiver of the tuition fees may be considered for a competitive international candidate.
This research project is available to PhD, Masters by Research, Honours, Master of Biomedical Science students to join as part of their thesis.
Please contact the supervisor to discuss your options.