Developing novel therapies for the treatment of retinal disease

Research Opportunity
PhD
Project Status
Future
Department
Medicine and Radiology
Location
St Vincent's Hospital
Supervisor Email Number Webpage
Dr Amanda Edgley aedgley@unimelb.edu.au +61 3 9231 3275 Personal web page
Dr Fay Khong ay.khong@unimelb.edu.au Personal web page

Project Details

Our group is focussed on the development of innovative therapeutic strategies for the treatment of ophthalmic disorders associated with retinal inflammation and fibrosis. Two key features of many of the leading causes of blinding eye disease is damage to the blood vessels in the retina at the back of the eye, causing them to bleed or leak fluid, distorting vision. More recently it has also been shown that inflammation in disease leads to activation of retinal microglial cells, which in turn release factors that drive the loss of both neural and vascular cells of the retina.  Currently, there are no effective treatment options retinal scarring and limited therapies for inflammation and neovascularisation.  Hence there is a high unmet clinical need for novel and cost effective products to enhance visual acuity and prevent vision loss associated with neovascularisation, inflammation and fibrosis.

With this focus, our group along with the biotech company OccuRx, has patented a library of new chemical entities with potent anti-inflammatory and anti-fibrotic properties to treat inflammatory and fibrotic diseases of the retina. Our projects involve testing the efficacy of novel compounds on the pathological (histological and molecular) features of various eye diseases using animal models and cell culture systems. We have a number of projects suitable for PhD students that are available to outstanding and enthusiastic students interested in pre-clinical drug development. We also welcome enquiries from students interested in the business development side of the Biotech Industry in Australia.

Researchers

Research Opportunities

This research project is available to PhD students to join as part of their thesis.
Please contact the supervisor to discuss your options.


School Research Themes

Cardiometabolic



Key Contact

For further information about this research, please contact a supervisor.

Department

Medicine and Radiology

Research Group / Unit / Centre

Biomedical Translational Research Group: Developing Therapies for Cardiovascular Disease

Research Node

St Vincent's Hospital