Development of scaffolds for restoration of myotendous junctions
- Research Opportunity
- PhD, Masters by Research, Honours, Master of Biomedical Science
- Project Status
- Medicine and Radiology
- St Vincent's Hospital
|A/Prof Robert Kapsafirstname.lastname@example.org||03 9288 3340||Personal web page|
Damage to muscle tissue resulting from trauma poses significant problems for orthopaedic surgeons attempting to save limbs and recover joint function. Likewise, it is currently beyond the scope of regenerative therapies to restore lost muscle function arising from disease-related loss of muscle tissue. World-wide, musculoskeletal conditions affect more than 1 in every 100 people and the prognosis for regeneration and long-term success for good functional outcomes is poor.
This project focuses on two aspects central to the restoration of compromised muscle; (i) re-establishing the myotendonous junction to restore articulation of limb joints.
Therefore, the key aims of this project are:
- To develop bioactive polymeric scaffolds that support implanted cultured myocytes and neurons to build 3D tissue suitable for restorative and regenerative surgery;
- To devise a biomimetic approach by using biologically active factors incorporated into the material structure of the scaffolds to promote the growth and differentiation of tissue to stimulate neuromuscular junction formation.
This project will utilize cultured adult stem cells that will be differentiated into required cell types on supporting 3D polymer scaffolds developed as part of a collaborative link with the Intelligent Polymer Research Institute at the University of Wollongong.
This research project is available to PhD, Masters by Research, Honours, Master of Biomedical Science students to join as part of their thesis.
Please contact the supervisor to discuss your options.
Faculty Research Themes
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For further information about this research, please contact a supervisor.