Predictors and mechanisms of cutaneous adverse drug reactions: a multi-omic approach
- Research Opportunity
- PhD, Masters by Research, Honours
- Project Status
- Medicine and Radiology
- Royal Melbourne Hospital
|Patrick Kwanfirstname.lastname@example.org||Personal web page|
Mainstream anti-epileptic drugs (AEDs) that are used to treat epilepsy and some other conditions are associated with a range of cutaneous side effects. Genetic analyses that compare the genomes of those who develop an adverse reaction with those that are tolerant to AEDs has identified specific genetic markers that increase susceptibility in some but not all individuals. It is increasingly understood that multiple genomic and /or environmental factors contribute to drug sensitivity.
A better understanding of the underlying molecular mechanisms will enhance capacity for personalised treatment and the design of safer drugs. This project represents a unique opportunity to investigate the underlying molecular mechanisms by integrating genomic analysis with transcriptomics (gene expression) approaches. The transcriptome, derived from T-cells, will be used to identify genes that are differentially expressed or that change their pattern of co-expression in cells from drug-exposed cases as compared to those from drug-tolerant controls. The student will be part of a multidisciplinary team with expertise in neurology, cell biology and bioinformatics and gain an understanding of the rapidly evolving field of pharmacogenomics.
This research project is available to PhD, Masters by Research, Honours students to join as part of their thesis.
Please contact the supervisor to discuss your options.
Faculty Research Themes
School Research Themes
For further information about this research, please contact a supervisor.