A neural systems model of fear dysregulation in anxiety disorders

Research Opportunity
PhD, Masters by Research, Honours, Master of Biomedical Science
Project Status
Future
Department
Psychiatry
Supervisor Email Number Webpage
A/Prof Ben Harrison habj@unimelb.edu.au (+613) 83441959 Personal web page
A/Prof Chris Davey c.davey@unimelb.edu.au Personal web page

Project Details

The medial prefrontal cortex is often centrally implicated in the pathophysiology of depression, although it remains unclear how disturbances in its functional interaction with other higher cortical brain regions may distinguish depressed from non-depressed individuals.

The aim of this project will be to clarify the role of the medial prefrontal cortex in depression by developing a computational neural model of dynamic functional interactions based on the analysis of resting-state brain functional magnetic resonance imaging (fMRI) data. This data has been recently collected and involves large samples of young people with moderate-to-severe depressive illness (N=120), and demographically matched healthy control participants (N=120). Associations with neural model parameters and clinical - including treatment response characteristics ¬- of the depressed participants will be examined in detail.

Research Opportunities

This research project is available to PhD, Masters by Research, Honours, Master of Biomedical Science students to join as part of their thesis.
Please contact the supervisor to discuss your options.



Faculty Research Themes

Neuroscience

School Research Themes

Neuroscience & Psychiatry



Key Contact

For further information about this research, please contact a supervisor.

Department

Psychiatry

Research Group / Unit / Centre