Monocytes in Multiple Sclerosis
- Research Opportunity
- PhD, Masters by Research, Honours, Master of Biomedical Science
- Project Status
- Medicine and Radiology
- Royal Melbourne Hospital
|Dr Mastura Moniffirstname.lastname@example.org||Personal web page|
|Professor Terry O'Brienemail@example.com||Personal web page|
Although multiple sclerosis (MS) is considered to be a disease of the central nervous system, there is a vast array of recent data implicating the contribution of the peripheral immune system in disease pathogenesis. In particular, the innate immune system, consisting of monocytes and dendritic cells which form the first line of defence against pathogens are thought to be important in disease initiation.
This project will examine the similarities and differences between the peripheral immune system in patients with MS versus healthy controls. The focus will be on monocytes and we will be looking at the various cytokines and chemokine profiles that are generated in the disease state versus control. We will also be looking at the effect of MS disease modifying therapy on monocyte function. Also at the time of disease relapse we will be characterizing various immune signatures and we will aim to decipher how prednisolone (which is a commonly prescribed medication for MS relapse) exerts its effects on the peripheral monocytes.
This project will improve our understanding of MS pathogenesis. By characterising monocytes function in MS we hope to develop targeted and effective therapies that combat disease initiation and relapse.
This research project is available to PhD, Masters by Research, Honours, Master of Biomedical Science students to join as part of their thesis.
Please contact the supervisor to discuss your options.