Monitoring for atypical femoral fracture (AFF) risk
- Research Opportunity
- PhD, Masters by Research, Honours, Master of Biomedical Science
- Project Status
- Medicine and Radiology
- Royal Melbourne Hospital
|Prof John Wark||Personal web page|
|Dr Chris Yates||Personal web page|
Evidence suggests that bisphosphonates and other antiresorptive therapy are associated with atypical fractures involving the femoral shaft. This adverse event may be related to treatment duration. As yet, no evidence-based protocol has been developed to monitor patients for this uncommon but serious adverse effect of therapy for osteoporosis, a very common and often disabling condition.
The aim of this project is to evaluate the utility of single-energy X-ray absorptiometry screening for femoral morphological changes predictive of AFF. Patients treated with antiresorptive medications for osteoporosis will be recruited for evaluation in the Bone Densitometry Unit when having clinical bone densitometry. A scoring system will be developed and applied to quantify AFF risk and will be compared with potential clinical predictors of risk.
This research project is available to PhD, Masters by Research, Honours, Master of Biomedical Science students to join as part of their thesis.
Please contact the supervisor to discuss your options.
Faculty Research Themes
School Research Themes
For further information about this research, please contact a supervisor.