M2 Polarization of microglia as a new approach targeting temporal lobe epilepsy

Research Opportunity
PhD, Masters by Research, Honours
Project Status
Future
Department
Medicine and Radiology
Location
Royal Melbourne Hospital
Supervisor Email Number Webpage
Dr. Idrish Ali idrish.ali@unimelb.edu.au
Prof. Terence O'Brien

Project Details

Brain inflammatory is a characteristic of epileptic disorders and may promote its development and progression by affecting brain cell death, structural connectivity and excitability. The inflammatory response involves an acute classical immune activation (M1) that releases pro-inflammatory mediators promoting disease progression.

It may also involve M2 activation that mediates anti-inflammatory mechanisms promoting repair. Here, we aim to compare in an animal model of epilepsy, the seizure related outcomes between strategies to induce an M2 immune activation using genetic approaches or an overall inhibition of inflammatory response. We hypothesize that modulating the neuroinflammatory responses will be protective against development of epilepsy.

Research Opportunities

This research project is available to PhD, Masters by Research, Honours students to join as part of their thesis.
Please contact the supervisor to discuss your options.



Faculty Research Themes

Neuroscience

School Research Themes

Neuroscience & Psychiatry



Key Contact

For further information about this research, please contact a supervisor.

Department

Medicine and Radiology

Research Node

Royal Melbourne Hospital