M2 Polarization of microglia as a new approach targeting temporal lobe epilepsy
- Research Opportunity
- PhD, Masters by Research, Honours
- Project Status
- Medicine and Radiology
- Royal Melbourne Hospital
|Dr. Idrish Aliemail@example.com|
|Prof. Terence O'Brien|
Brain inflammatory is a characteristic of epileptic disorders and may promote its development and progression by affecting brain cell death, structural connectivity and excitability. The inflammatory response involves an acute classical immune activation (M1) that releases pro-inflammatory mediators promoting disease progression.
It may also involve M2 activation that mediates anti-inflammatory mechanisms promoting repair. Here, we aim to compare in an animal model of epilepsy, the seizure related outcomes between strategies to induce an M2 immune activation using genetic approaches or an overall inhibition of inflammatory response. We hypothesize that modulating the neuroinflammatory responses will be protective against development of epilepsy.
This research project is available to PhD, Masters by Research, Honours students to join as part of their thesis.
Please contact the supervisor to discuss your options.