Long-term prognosis of antiepilpetic drug therapy in people with newly diagnosed and treated epilepsy

Research Opportunity
PhD, Masters by Research, Honours
Project Status
Future
Department
Medicine and Radiology
Location
Royal Melbourne Hospital
Supervisor Email Number Webpage
Patrick Kwan Personal web page
Ben Chen

Project Details

Antiepileptic drug is the mainstay of treatment modality for epilepsy. People with epilepsy often require lifelong antiepileptic drug treatment. Previous Glasgow study in 2000 demonstrated a-third of the epilepsy patient did not response well to antiepileptic drug therapy. Despite the introduction of more than a dozen new antiepileptic drugs in the past two decades, there remain no robust data to suggest improvement in treatment outcomes in the recent expanded Glasgow study. To valid the prognosis and antiepileptic drug response patterns observed in the Glasgow studies.

We will assess treatment outcomes of 796 newly treated epilepsy patients who were seen at a First Seizure Clinic between 1 May 1999 and 31 May 2016 and were prospectively followed for up to 16 years in Australia. We will extract seizure, diagnostic and treatment information from baseline and follow-up clinical documents and construct a digital database. The prognosis and response patterns in the Australia cohort will be compared with the findings in the Glasgow study.

Research Opportunities

This research project is available to PhD, Masters by Research, Honours students to join as part of their thesis.
Please contact the supervisor to discuss your options.



Faculty Research Themes

Neuroscience

School Research Themes

Neuroscience & Psychiatry



Key Contact

For further information about this research, please contact a supervisor.

Department

Medicine and Radiology

Research Group / Unit / Centre

Epilepsy and Precision Medicine

Research Node

Royal Melbourne Hospital