Investigating the interaction between skeletal muscle and bone

Research Opportunity
PhD, Masters by Research, Honours, Master of Biomedical Science
Project Status
Future
Department
Medicine and Radiology
Location
St Vincent's Hospital
Supervisor Email Number Webpage
Dr Jonathan Gooi jgooi@unimelb.edu.au 9288 2598 Personal web page

Project Details

Skeletal muscle has a close functional relationship with bone. Both show major changes during aging and in the same way, sarcopenia and osteoporosis both contribute to frailty. Throughout life, the tissue mass of bone and muscle are intimately connected. Increases in muscle and bone mass result from weight-bearing exercise, while disuse results in the loss of both. For example muscular dystrophies are associated with relatively low bone density and an increased incidence of fractures. Conversely, significant increases in muscle mass are associated with increases in bone mineral density. Despite these observations, the precise mechanisms responsible for synchronizing bone and skeletal mass remains unclear.

While the ability of skeletal muscle to secrete growth factors and cytokines is well established, the impact of the skeletal muscle secretome on bone is less well understood. For example, how do muscle and bone cells communicate and regulate each other’s functions? Does the skeletal muscle secretome differ based on the type of muscle activity, disuse or damage? Are these signals dependent on mechanical stimulation and what effects do loading/unloading have? Finally, do bone-derived signals influence skeletal muscle function? Therefore the aim of this project is to investigate cellular communication between muscle and bone cells.

Research Opportunities

This research project is available to PhD, Masters by Research, Honours, Master of Biomedical Science students to join as part of their thesis.
Please contact the supervisor to discuss your options.


School Research Themes

Musculoskeletal



Key Contact

For further information about this research, please contact a supervisor.

Department

Medicine and Radiology

Research Group / Unit / Centre

Basic Musculoskeletal Biology

Research Node

St Vincent's Hospital