Investigating the interaction between skeletal muscle and bone
- Research Opportunity
- PhD, Masters by Research, Honours, Master of Biomedical Science
- Project Status
- Medicine and Radiology
- St Vincent's Hospital
|Dr Jonathan Gooifirstname.lastname@example.org||9288 2598||Personal web page|
Skeletal muscle has a close functional relationship with bone. Both show major changes during aging and in the same way, sarcopenia and osteoporosis both contribute to frailty. Throughout life, the tissue mass of bone and muscle are intimately connected. Increases in muscle and bone mass result from weight-bearing exercise, while disuse results in the loss of both. For example muscular dystrophies are associated with relatively low bone density and an increased incidence of fractures. Conversely, significant increases in muscle mass are associated with increases in bone mineral density. Despite these observations, the precise mechanisms responsible for synchronizing bone and skeletal mass remains unclear.
While the ability of skeletal muscle to secrete growth factors and cytokines is well established, the impact of the skeletal muscle secretome on bone is less well understood. For example, how do muscle and bone cells communicate and regulate each other’s functions? Does the skeletal muscle secretome differ based on the type of muscle activity, disuse or damage? Are these signals dependent on mechanical stimulation and what effects do loading/unloading have? Finally, do bone-derived signals influence skeletal muscle function? Therefore the aim of this project is to investigate cellular communication between muscle and bone cells.
This research project is available to PhD, Masters by Research, Honours, Master of Biomedical Science students to join as part of their thesis.
Please contact the supervisor to discuss your options.