How does PTHrP stimulate bone formation?

Research Opportunity
PhD
Project Status
Future
Department
Medicine and Radiology
Location
St Vincent's Hospital
Supervisor Email Number Webpage
A/Prof Natalie Sims Personal web page

Project Details

Parathyroid hormone related protein (PTHrP) is produced locally within bone, and stimulates bone formation. Even though it acts through the same receptor as parathyroid hormone (PTH), PTHrP has additional non-receptor mediated actions but these remain poorly described.

Our latest data indicates that PTHrP acting within osteocytes, the internal network of bone, stimulates bone formation and is needed for normal bone strength. Part of this action seems to occur by non-receptor mediated pathways. This project will identify those pathways and begin to explore how they regulate bone strength.

The project will use small animal techniques, histology and histomorphometry, micro-computed tomography, quantitative PCR, confocal microscopy, bone cell culture techniques, microarray and RNA-Seq methods and bioinformatics.

This project is conducted in St Vincent’s Institute of Medical Research, Bone Cell Biology and Disease Unit.

Research Opportunities

This research project is available to PhD students to join as part of their thesis.
Please contact the supervisor to discuss your options.


School Research Themes

Musculoskeletal



Key Contact

For further information about this research, please contact a supervisor.

Department

Medicine and Radiology

Research Group / Unit / Centre

Research Node

St Vincent's Hospital