How does bone matrix composition determine bone strength?
- Research Opportunity
- Honours, Master of Biomedical Science
- Project Status
- Medicine and Radiology
- St Vincent's Hospital
|A/Prof Natalie Sims||Personal web page|
Although bone strength is partially determined by the amount of bone in the skeleton, the material composition of bone also influences its strength.
We have developed a new method using the Australian Synchrotron Infra-Red beamline to assess bone composition in cortical bone, which allows us to study the process by which bone matrix becomes mineralized and how this determines bone strength. This project will examine a range of bone samples from different genetically altered mouse models, and under different physiological stresses by synchrotron-based Fourier-Transform Infra-red Microspectroscopy to provide new insights into how bone composition controls bone strength.
This project will use histology and histomorphometry, micro-computed tomography, synchrotron-based Fourier-Transform Infra-red Microspectroscopy, and spectral analysis techniques.
This project is conducted in St Vincent’s Institute of Medical Research, Bone Cell Biology and Disease Unit.
This research project is available to Honours, Master of Biomedical Science students to join as part of their thesis.
Please contact the supervisor to discuss your options.