The role of FANCM gene in inherited breast cancer
- Research Opportunity
- PhD, Masters by Research, Honours, Master of Biomedical Science
- Project Status
- Medicine and Radiology
- St Vincent's Hospital
|Dr Andrew Deans||Personal web page|
1 in 10 breast cancers are due to inheritance of a predisposing gene. In half of these cases, the inherited gene mutation is in the well characterised BRCA1 or BRCA2 genes. The normal function of BRCA1 and BRCA2 is in DNA repair, to suppress cancer by removing the damage to DNA that is caused by carcinogens. Over the last few years, many other DNA repair genes have been linked with familial breast cancer, including the FANCM gene.
Our lab studies the mechanism of DNA repair by the FANCM protein using cell-based and protein chemistry-based approaches. This project will test the breast-cancer associated FANCM mutations in a set of assays so that we may determine why they predispose to breast cancer.
A combination of approaches will be used such as studies on chemotherapy toxicity, analysis of the FANCM knockout mouse, and purification of recombinant human FANCM using state-of-the-art protein expression systems. This project will be part of a larger Cancer Council-funded study into the role of DNA repair in cancer initiation and chemotherapy.
This project is conducted in St Vincent’s Institute of Medical Research, Genome Stability Unit.
This research project is available to PhD, Masters by Research, Honours, Master of Biomedical Science students to join as part of their thesis.
Please contact the supervisor to discuss your options.